xGen Lockdown Probes are individually synthesized 5′-biotinylated oligos for hybridization capture enrichment in next generation sequencing. xGen Lockdown Probes are produced using the same industry-leading, high-fidelity synthesis chemistry developed for Ultramer Oligonucleotides.
These probes can be used for creating custom capture panels that can be optimized, expanded, and combined with other panels. xGen Lockdown Probe Pools can also be used to enhance the performance of existing capture panels, rescuing poorly represented
regions, such as areas of high GC content.
With xGen Lockdown Probes, you can:
- Design probes for any sequence in any species using your specified parameters for target definition, probe length, and tiling density
- Add probes for custom targets like untranslated regions (UTRs), introns, and fusions to complement human xGen Predesigned Gene Capture Pools
- Easily transition to high volume applications with custom production scales
Use gene symbols, gene IDs, and BED files to identify human, mouse, and rat gene targets. Alternatively, the design tool also accepts RefSeq accession numbers or FASTA-formatted sequences.