ASOs, miRNA Inhibitors, & RNAi Products

Chemically modified DNA oligos that modulate gene expression through the RNase H pathway, steric blocking, or splicing modulation.

Silences gene expression by degrading mRNA via the RISC complex. RNA duplexes optimized for knockdown of cytoplasmic RNA.

14–24

14–24

12–36

27

(24-30 allowed)

18-23

16–26

Custom ASO design services via Application Support Team

Predesigned, custom design, custom entry

Design guidance/support is available

Sequence configurator

DNA, PS, 2’MOE

DNA, PS, Affinity Plus

DNA, PS, 2’MOE, Affinity Plus, 2’OMe, 5’Methyl dC, 2’F

DNA bases at 3’ end of sense strand to prevent sense-strand loading. (DsiRNA only)

RNA, 2'F, 2'OMe, DNA, and PS linkage modifications available

2’OMe, ZEN

Tubes, plates

Tubes, plates

Tubes

5, 10, 50, 200 nmol (with optional HPLC purification)

2, 10 nmol

5, 20, 250 nmol

RNase H1-mediated gene knockdown targeting cellular RNAs, splice modulation, blocking translation and blocking RBP binding, HT screening

Gene silencing, HT screening

miRNA functional studies, HT scr eening