Prof. Andre Franke

CCGA Kiel offers a broad portfolio of sequencing services fitting the needs of academic partners, including different long-read technologies. Long-read sequencing has the potential to overcome several challenges in genomic sequencing as long reads covering several heterozygous SNVs can be used to generate haplotype-phased data. Longer stretches containing highly paralogous or repetitive sequences can reliably be aligned to their genomic origin and be resolved.

Despite recent throughput improvements, long-read sequencing for hypothesis-driven studies including larger cohorts is still unaffordable for many. With high-throughput and automatization-capable targeted enrichment protocols for long genomic fragments, CCGA Kiel enables large cohort studies for small or comprehensive enrichment panels. The group’s aim is to empower researchers to leverage the potential of long-read sequencing for everyone, including the most complex genomic loci.