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Ultima Genomics

Unleash the power of genomics at scale

Ultima Genomics is unleashing the power of genomics at scale. The company's mission is to continuously drive the scale of genomic information to enable unprecedented advances in biology and improvements in genomic research. Ultima's revolutionary new sequencing architecture drives down the costs of sequencing to help overcome the tradeoffs that scientists are forced to make between the breadth, depth, and frequency with which they use genomic information. Ultima Genomics’ novel massively parallel sequencing platform, the UG 100™, combines multiple innovative technologies, including an open flow cell design, a mostly natural chemistry that uses nucleotides without reversible terminators, and optical end-point detection, all to enable the sequencing of billions of reads with longer read lengths (~300 bp) and fast run times (<20 hrs) at high accuracy (Q30 > 85%) and a low cost of $1/Gb.

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xGen cfDNA and FFPE DNA Library preparation for sequencing using Ultima Genomics UG 100 Demonstrated Protocol

This demonstrated protocol describes the workflow for preparing libraries for whole genome sequencing (WGS)
on the UG 100 sequencing platform from Ultima Genomics. For sequencing, the UG 100 system requires libraries
containing a UG 100 specific Index Primer and an UG Universal Primer sequence containing an overhang.

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Whole Genome Sequencing and High-Efficiency Library Preparation for Generating and Detecting MRD Signatures Application Note

Here, we use the IDT xGen™ cfDNA & FFPE Library Prep Kit to prepare FFPE and cfDNA libraries for Whole Genome Sequencing (WGS) using the UG 100™ sequencer and demonstrate the utility of these combined technologies for identifying mutation signatures in low-quality FFPE and sensitive detection of circulating tumor DNA (ctDNA) in clinical research plasma samples with low tumor fractions.

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