Processing
Archer™ IMMUNOVerse™ TCR panel
Assess clonalities, TILs, and more with a targeted RNA assay
Characterize T-cell clonalities, MRD, and detection of tumor infiltrating lymphocytes (TIL) as well as profile the immune repertoire with targeted NGS of T-cell receptor chain RNA relevant for blood cancer and solid tumor research.
Clarify the immune repertoire with Archer IMMUNOVerse NGS Panels for RNA.
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Learn how the IMMUNOVerse TCR panel can identify key genomic alterations for your research.
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Panel specifications
| Specifications | |
|---|---|
| Target regions | TCR beta, gamma, alpha, and delta chains |
| Applications | Clonality, MRD, TILs, profiling |
| Input RNA required* | 20 ng to 2 μg |
| Recommended number of reads* | 250K to 10M |
| Hands-on time | 3.5 hours |
| Total library prep time | 1.5 days |
| Platform compatibility | Illumina® |
| Reagent format | Lyophilized |
| Supported sample types | Blood, PBMC, sorted T cells, FFPE or fresh frozen tissue |
*Input mass and read requirements vary depending on type, quality, T cell content, and application.
Benefits
- Identify more—Anchored Multiplex PCR (AMP™) chemistry amplifies effectively through hypervariable sequences and variable length fragments enabling rare clone detection, even for potentially degraded FFPE tissue.
- Clarify confidently—Archer Analysis corrects for amplification bias and sequencing errors to provide a true and reproducible measure of diversity and can be used for disease monitoring, repertoire profiling, and studying tumor infiltrating lymphocytes.
- Secure data—Assessing samples in-house means you retain important data for further studies, ensuring all your data remains user-owned.
- Achieve efficiency—Parallel workflows across all Archer panels provides streamlined genomic characterization, while single use, reaction-sized lyophilized reagents minimize hands-on time and potential pipetting errors.
Interested in more genomic characterization?
Discover or design NGS panel content that fits your lab’s solid tumor or blood cancer research needs with Assay Marketplace.
Ready to start?
Talk with our technical sales team. Learn how the IMMUNOVerse TCR panel can identify key genomic alterations for your research.
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Frequently asked questions
Can I analyze solid tumor DNA and RNA simultaneously for comprehensive genomic profiling with Archer panels?
Yes, DNA and RNA from a single sample can be analyzed with VARIANTPlex™ and FUSIONPlex™ panels to provide a genomic profile of the cancer. For comprehensive genomic profiling, pair VARIANTPlex Complete Solid Tumor and FUSIONPlex Pan Solid Tumor v2 panels to interrogate 511 genes for SNVs, indels, CNVs, fusions, exon-skipping, and splicing variants, as well as assessment of MSI and TMB. Additionally, the IMMUNOVerse™ TCR panel can provide tumor-infiltrating lymphocyte information relevant for solid tumor characterization. All Archer panels have parallel workflows, allowing for streamlined comprehensive solid tumor profiling.
Can IMMUNOVerse™ provide relevant information for solid tumors?
Yes, the IMMUNOVerse TCR panel can provide information on tumor infiltrating lymphocytes (TILs), which are important biomarkers in several solid tumors, including lung, breast, colon, melanoma, sarcoma, and gliomas. IMMUNOVerse panels have parallel workflows with VARIANTPlex™ and FUSIONPlex™ panels, allowing for comprehensive, streamlined profiling of solid tumors.
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