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Anchored Multiplex PCR (AMP™) is a targeted next-generation sequencing (NGS) library preparation method designed to detect genomic alterations in challenging sample types, including highly degraded input materials like FFPE. AMP uses multiple “anchored” gene-specific primers (GSPs) that amplify opposite a single universal primer. This open-ended, anchored amplification makes AMP highly effective for discovering simple, novel, and complex rearrangements