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Short hybridization times (e.g., 1-2 hours) are supported and can deliver comparable targeting performance under many conditions, but some trade-offs should be considered. The following considerations may apply:
1. Coverage and yield: shorter hybridization may result in slightly lower capture yield or coverage depth, particularly with low input.
2. Input dependence: higher total inputs with shorter hybridization times may show minor differences in metrics such as GC skew or yield under some conditions.
3. Panel design effects: performance with short hybridization can depend on panel size and probe design as coverage behavior reflects panel characteristics rather than workflow bias.
4. Application needs: for applications requiring maximum uniformity or depth, longer hybridization times may still be preferred.