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Base editing is the preferred approach for rapid and efficient correction of compatible single-base mutations, specifically C→T or A→G conversions. Prime editing is better suited for precise modifications beyond these transitions, including other base substitutions and small insertions or deletions, while avoiding the creation of double-strand DNA breaks. HDR-mediated CRISPR editing can also achieve substitutions, insertions, deletions, and even larger sequence replacements. However, HDR-based approaches generally exhibit lower editing efficiency and may carry a higher risk of off-target effects and genotoxicity.