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Both Alt-R HDR Enhancers can be used in the same experiment and can have an additive effect on rates of HDR. The two enhancers are delivered to cells differently and at different steps during CRISPR editing. Though the Alt-R HDR Enhancer Protein often results in a smaller increase in HDR than the Alt-R HDR Enhancer V2 in some cell lines, the Alt-R HDR Enhancer Protein has a better off-target and toxicity profile and the CGMP version will be available soon to address the critical need for clinical applications.
Learn more: Alt-R™ HDR Enhancer Protein: Improving homology-directed repair from bench to bedside