Dicer-substrate RNA (DsiRNA) is used to target physiological pain modulators in animal models for in vivo pain research.
In situ detection of mature microRNAs via labeled extension of Ultramer templates is used to detect human miR-212 expression patterns.
Use of a novel CpG-motif oligonucleotide delivery tool to deliver anti-STAT3 DsiRNA to TLR9-positive cells, where Dicer cleavage releases the mature siRNA from the CpG ligand.
Microfluidic screening of aptamers to the light chain of recombinant Botulinum neurotoxin type A. The DNA library was comprised of sequences containing a central random region of 60 bases flanked by 2 specific 20-base sequences, and was synthesized and purified by IDT.
Use of aptamers and aptamer–siRNA chimeras to inhibit HIV-1 replication and infectivity in cultured human CEM T cells and primary blood mononuclear cells.
Sets of hybridized, high-fidelity Ultramer Oligonucleotides were assembled into large constructs in a single step. Such constructs are available from IDT as gBlocks® Gene Fragments.